Charlotte Frederica of Mecklenburg-Schwerin (4 December 1784 – 13 July 1840), was the first wife of King Christian VIII from 1806 until 1810, before he became King of Denmark. She was a daughter of Frederick Francis I, Grand Duke of Mecklenburg-Schwerin, and Princess Louise of Saxe-Gotha-Altenburg.
Charlotte Frederica was born at Ludwigslust in the Duchy of Mecklenburg. She married Prince Christian of Denmark and Norway, heir apparent to the throne of Denmark, in 1806. In 1808, she gave birth to her husband's only surviving son, the future King Frederick VII of Denmark.
Duchess Charlotte Frederika allegedly had an affair with the French singer and composer Édouard Du Poy. For this reason, her husband divorced her in 1810, sent her into internal exile, and prohibited her from seeing her son again.
After her divorce, Charlotte Frederica spent the next years of her life in a palace in Horsens, in Jutland, where she cultivated amorous affairs with local officers. In 1830, she traveled to Italy, finally settling in Rome. She later converted to the Catholic faith. Charlotte Frederica died in Rome in 1840.