Floride Bonneau Calhoun (February 15, 1792 – July 25, 1866) was the wife of prominent U.S. politician John C. Calhoun.
She was born Floride Bonneau Colhoun to U.S. Senator John E. Colhoun and Floride Bonneau. She was a niece of Rebecca Colhoun Pickens, wife of Andrew Pickens. On January 8, 1811, she married John C. Calhoun, her first-cousin-once-removed (her father's first cousin). Soon after their marriage, her husband was elected to Congress, leaving his wife in charge of his plantation, "Fort Hill," in present-day Clemson, South Carolina. Within the next eighteen years, she gave birth to ten children, including five sons and five daughters, although three daughters died in infancy.
In 1817, she accompanied her husband to Washington upon his appointment as Secretary of War.
Eight years later, she became Second Lady of the United States, with her husband's election as Vice President, serving in that role from 1825 to 1832.
During her tenure as Second Lady, she became embroiled in a social scandal involving Margaret O'Neill Eaton, the wife of Secretary of War John Eaton, in what became known as the Petticoat affair.