Isaac McCoy (June 13, 1784 - June 21, 1846) was a Baptist missionary among the Native Americans in present-day Indiana, Michigan and Missouri. He was an advocate of Indian removal from the eastern United States, proposing an Indian state in what is now Kansas, Nebraska, and Oklahoma. He also played an instrumental role in the founding of Grand Rapids, Michigan and Kansas City, Missouri.
McCoy was born in Uniontown, Pennsylvania. In 1789, the McCoys, father, mother and six children, rafted down the Ohio River to Kentucky, settling first near Louisville and ln 1792 in Shelby County. Isaac McCoy's father was a Baptist Minister and the son followed in his footsteps. He departed Kentucky for Vincennes, Indiana in 1804 shortly after his marriage to Christiana Polke, age 16, a cousin of future President James K. Polk. Although he had no training and little formal education he became a part time preacher. In 1808 the Silver Creek Baptist Church, the first Baptist Church in Indiana, granted McCoy a license "to preach the Gospel wherever God in His providence might cast his lot.” In 1809 McCoy became pastor of Maria Creek Church near Vincennes and in 1810 the Church ordained him.