Margaret of Savoy (1410–1479) was a daughter of Amadeus VIII of Savoy and Mary of Burgundy. By her three illustrious marriages, she held a number of titles, including Duchess of Anjou, Duchess of Calabria, Countess of Maine, Countess Palatine of the Rhine, and Countess of Württemberg.
Margaret was one of seven children born to Amadeus VIII, Count of Savoy and his wife Mary of Burgundy. A few of her siblings included Louis, Duke of Savoy and Mary, Duchess of Milan.
Her paternal grandparents were Amadeus VII, Count of Savoy and Bonne of Berry. Her maternal grandparents were Philip the Bold, Duke of Burgundy and Margaret III, Countess of Flanders.
Margaret married firstly Louis, Duke of Anjou, the titular King of Naples. He was a son of Louis II of Anjou and Yolande of Aragon. Their first marriage contract is dated on 31 Mar 1431. She became known as the Duchess of Anjou. They had no children, and he died in 1434.
In 1445, Margaret next married Louis IV, Count Palatine of the Rhine. He was a son of Louis III, Elector Palatine and his second wife Matilda of Savoy. Margaret became Countess Palatine of the Rhine through this alliance.