Samuel Prescott Hildreth (1783–1863) was a pioneer physician, scientist, and historian, authoring numerous scientific and historical works. His history books are largely based on first-person accounts and primary documents, providing insight into the early settlement of Marietta, Ohio and the Northwest Territory and the lives of early pioneers.
Samuel Prescott Hildreth was born in Methuen, Massachusetts on September 30, 1783. His father, Dr. Samuel Hildreth of Massachusetts, was a physcian with a regiment of volunteers during the American Revolutionary War, served as surgeon aboard a privateer, and became a prisoner-of-war. Samuel Prescott Hildreth was educated at the Phillips Academy at Andover, Massachusetts. He began medical studies under his father, completed studies under care of Dr. Thomas Kittredge of Andover, and received his diploma in 1805 after examination by the Massachusetts Medical Society. He subsequently practiced medicine in Hampstead, New Hampshire until relocating to Ohio in 1806.
His father, Samuel Hildreth, was a shareholder in the Ohio Company of Associates, and had considered moving to Ohio.